Vascular endothelial growth factor gene transfer for diabetic polyneuropathy

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Vascular endothelial growth factor gene transfer for diabetic polyneuropathy: a randomized, double-blinded trial.

OBJECTIVE Randomized, blinded trial of intramuscular gene transfer using plasmid vascular endothelial growth factor (VEGF) to treat diabetic polyneuropathy. METHODS Diabetic patients with polyneuropathy were randomized to receive a VEGF-to-placebo ratio of 3:1. Three sets of injections were given at eight standardized sites adjacent to the sciatic, peroneal, and tibial nerves of one leg. Prim...

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ژورنال

عنوان ژورنال: Annals of Neurology

سال: 2009

ISSN: 0364-5134,1531-8249

DOI: 10.1002/ana.21686